Dan Benjamin's Win the SPAM Arms Race offers a clever way to create a clickable mailto: link on your web pages while greatly reducing the ability of spam harvesters to find it. Some people are so nice.
I'm combining that with some email filters, started with Heather's list plus a few additions that are working well. So far I'm filtering on:
[ a blank subject line ]
I still find myself looking through the spam I've caught, like sorting through the odd creatures entrapped in the net before throwing them back.